Tricarboxylic acids and derivatives
Medchemexpress LLC Pacritinib (citrate) | 1228923-42-9 | 99.7% | 664.70 | 1 ML
Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). It also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). This compound can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF).
- Potent inhibitor of wild-type JAK2 (IC50=23 nM)
- Potent inhibitor of JAK2V617F mutant (IC50=19 nM)
- Inhibits FLT3 (IC50=22 nM)
- Inhibits FLT3D835Y mutant (IC50=6 nM)
- Used for research in acute myeloid leukemia (AML) and myelofibrosis (MF)
Medchemexpress LLC m-PEG8-CH2COOH | 102013-72-9 | 99.9% | 5 G
m-PEG8-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It has a molecular weight of 442.50 and a chemical formula of C19H38O11. This compound appears as a colorless to light yellow liquid with a density of 1.122 g/cm3. For in vitro solubility, it dissolves in DMSO at 200 mg/mL.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Molecular weight: 442.50
- Formula: C19H38O11
- Appearance: liquid
- Color: colorless to light yellow
- In vitro solubility: 200 mg/mL in DMSO
- Pure form storage: stable for 3 years at -20°C or 2 years at 4°C
- In solvent storage: stable for 6 months at -80°C or 1 month at -20°C
Selleck Chemical LLC Ixazomib Citrate (MLN9708) S4432-25mg
Ixazomib Citrate (MLN9708) is a prodrug of Ixazomib (MLN2238) which is a selective orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic ( 5) site with IC50 of 3 4 nM and Ki of 0 93 nM respectively Ixazomib (MLN2238) also inhibits caspase-like ( 1) and trypsin-like ( 2) proteolytic sites with IC50 of 31 nM and 3500 nM respectively
Medchemexpress LLC Bromo-PEG1-CH2COOH | 1135131-50-8 | >=97.0% | 100 MG
Bromo-PEG1-CH2COOH is a PROTAC linker, designed for use in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, by connecting an E3 ubiquitin ligase ligand to a target protein ligand.
- Used as a PROTAC linker
- Designed for PROTAC synthesis
- Contains two ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- Other ligand targets a protein
- Exploits the ubiquitin-proteasome system
- Enables selective degradation of target proteins
- For research use only
Medchemexpress LLC HO-PEG-CH2COOH | 10000 | HO-(CH2CH2O)n-CH2COOH | 500 MG
HO-PEG-CH2COOH (MW 10,000) is a polyethylene glycol (PEG) polymer terminated with a hydroxyl group and a terminal carboxylic acid. The manufacturer describes it as suitable for use as a PROTAC linker in the synthesis of PROTAC molecules and supplies product documentation including a data sheet and SDS.
Medchemexpress LLC 5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester | 391684-36-9 | ≥98.0% | C19H37NO10 | 250 MG
Boc-NH-PEG6-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. These compounds consist of two distinct ligands, connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
- Contains two different ligands connected by a linker.
Medchemexpress LLC Dicresulene diammoni 50mg | 50MG
Dicresulene diammonium is an impurity of Policresulen an organic acid with hemostatic antimicrobial and antiviral activities[1 [2
Medchemexpress LLC SPD-473 citrate | 161190-26-7 | MFCD31382144 | 99.8% | 552.47 g/mol | C23H31Cl2NO8S | 1 MG
SPD-473 citrate is the citrate salt of a triple reuptake inhibitor that blocks serotonin, dopamine, and norepinephrine transporters. Supplied for research use, it is a characterized white to off-white solid with documented purity and solubility data for in vitro and in vivo studies.
- Acts as a serotonin, dopamine, and norepinephrine reuptake inhibitor.
- High purity (99.8%).
- Molecular weight 552.47 g/mol.
- White to off-white solid suitable for laboratory handling.
- High solubility in DMSO (100 mg/mL); in vivo formulation protocols provided.
- Available in 1 mg, 5 mg, 10 mg, and 25 mg pack sizes for screening and pilot studies.
Medchemexpress LLC Boc-NH-PEG6-CH2COOH | 391684-36-9 | ≥98.0% | C19H37NO10 | 100 MG
Boc-NH-PEG6-CH2COOH is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. This compound is for research use only and not intended for patient use. It helps exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Molecular weight: 439.50
- Appearance: Colorless to light yellow liquid
- Density: 1.134±0.06 g/cm3
- Shipping at room temperature (continental US)
- Storage (pure form): -20°C for 3 years or 4°C for 2 years
- Storage (in solvent): -80°C for 6 months or -20°C for 1 month
![Medchemexpress LLC Methyl 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate | 544450-68-2 | 99.9% | C16H16ClNO3S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260202.png-250.jpg)
Medchemexpress LLC Methyl 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate | 544450-68-2 | 99.9% | C16H16ClNO3S | 10MG
COR659 (methyl 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate; CAS 544450-68-2) is a small-molecule positive allosteric modulator of the GABAB receptor used in preclinical neuroscience and addiction research. It has been reported to reduce alcohol- and chocolate-seeking behavior in rodent models and is supplied as a high-purity research chemical for in vitro and in vivo pharmacology studies.
- Potent GABAB positive allosteric modulator with demonstrated in vivo activity.
- High purity suitable for research applications.
- Well characterized chemical identifiers and molecular formula.
- Off-white solid form compatible with standard solvents such as DMSO.
- Storage and handling guidance provided for refrigerated and cryogenic conditions.
Medchemexpress LLC Gefapixant citrate | 2310299-91-1 | 99.2% | 545.5 g/mol | C20H27N5O11S | 1 ML
Gefapixant citrate is a P2X3 receptor antagonist provided as a concentrated solution for laboratory research. The reagent is supplied at 10 mM in DMSO (1 mL) and is intended for in vitro pharmacology and biochemical studies, with analytical documentation available from the manufacturer.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- High purity (99.2%) suitable for research applications.
- Supports in vitro P2X3 receptor pharmacology and biochemical assays.
- Comes with data sheet, certificate of analysis, and safety data sheet.
- For research use only; not for human or diagnostic use.
Medchemexpress LLC DiMal-O-CH2COOH | 1620837-47-9 | 96.81% | C13H12N2O7 | 100 MG
diMal-O-CH2COOH is a cleavable ADC linker. It is for research use only and not intended for human use. This product appears as a solid with a white to off-white color.
- Cleavable ADC linker
- For research use only
- Not intended for human use
- Appears as a solid
- Color: white to off-white
- Molecular weight: 308.24
Medchemexpress LLC diMal-O-CH2COOH | 1620837-47-9 | 96.8% | C13H12N2O7 | 5 MG
diMal-O-CH2COOH is a cleavable ADC linker, intended for research use only.
- Solid appearance, white to off-white color.
- Shipping at room temperature in continental US.
- Store at 4°C, protected from light and under nitrogen.
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light and under nitrogen.
- Relevant for cancer and cancer targeted therapy research.
Medchemexpress LLC PEG3-O-CH2COOH (PROTAC Linker 8) | 51951-05-4 | ≥95.0% | 100 MG
PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based PROTAC linker designed for use in the synthesis of SNIPERs. These SNIPERs recruit inhibitor of apoptosis protein (IAP) ubiquitin ligases to specifically degrade targeted proteins, offering a valuable tool for research applications.
- PEG-based PROTAC linker
- Used in the synthesis of SNIPERs
- Recruits inhibitor of apoptosis protein (IAP) ubiquitin ligases
- Designed to specifically degrade targeted proteins
- For research use only